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When the United States entered World War I, Opie took a leave of absence from WUSM to enter the U. Army and he served in France as a Colonel in the Medical Corps, with special work on infectious diseases and their prevention among allied soldiers. Significant new data were accrued on influenza, tuberculosis, and trench fever during that time, upon returning to civilian life, Opie continued his duties at WUSM until 1923.]